Amala Ruth De Vere Whelan, 22, was raped and murdered at her home in Maida Vale on 12 November 1972.
The popular CND activist was found dead at the flat at 61 Randolph Avenue four days later on 16 November.
She had been beaten and strangled with a stocking. There was no sign of forced entry, leading detectives to believe she either knew her attacker or let him into the flat.
The word 'ripper' had been sprayed on to the front room wall with detergent from a bottle of washing up liquid.
Despite an extensive investigation no suspect was identified and the case remains unsolved.
In January 2017 a new appeal was launched by Detective Inspector Susan Stansfield, from the Met's Special Casework Investigation Team at the Homicide and Major Crime Command,
She said: "More than 44 years have now passed since Amala’s death but I am convinced that someone, somewhere, knows the circumstances of her brutal murder. It was a long time ago but I'm sure there are people in the local area who remember Amala’s murder.
“Did you live in the vicinity of Randolph Avenue in the early 1970s? Did you see or hear anything suspicious on 12 November 1972?"
Police are particularly interested in tracing any friends and relatives of Amala. At the time of her death, Amala had a younger sister aged about 12 years old, who would now be about 56 years of age.
DI Stansfield continued: "Amala suffered a brutal death and the identity of the suspect has remained a mystery. She was a very popular and attractive female who had a wide social network of friends. She was an active member of the CND party, and had numerous friends in the art world.
“If you have any information, no matter how insignificant you think it might be, please come forward. Maybe you didn't contact police at the time as you were too scared, but with the passage of time now feel able to tell us what you know in confidence."
Amala had worked and lived at The Bar Lotus on Regents Park Road in Camden before moving to the Randolph Avenue flat about three weeks before her death.
The original appeal poster stated that she was last seen alive at 10.30pm on 12 November 1972 at the Warrington Public House in Sutherland Avenue, Maida Vale.
She was described as 5ft 5 inches tall with long brown hair and wearing a purple coat and multi-coloured long dress.
Anyone with information is asked to contact police on 020 7230 4294 or Crimestoppers anonymously on 0800 555 111.