Syed Jamanoor Islam, 20, was stabbed to death in Mile End on 11 April 2017.
The business student was out with friends when they were confronted by a group of men in Wager Street.
Police were called to the scene at around 4.46pm and he was pronounced dead at hospital just after 5.30pm.
A post-mortem confirmed the cause of death was a stab wound.
Detectives arrested four men aged between 15 and 18 on suspicion of murder. On 17 April 2017 Nayeem Chowdhury, 18 (03.02.99) of Burdett Road, E14, a 15-year-old boy from Seven Kings, and a 17-year-old boy from Bow were charged with murder.
The Met's Homicide and Major Crime Command are investigating under Detective Chief Inspector Tony Lynes.
DCI Lynes said: "We are keen to speak to anyone who was in the area at that time and might have seen what happened or who has any information about the circumstances."
Anyone who can help is asked to contact the incident room on 020 8721 4868 or via @MetCC.
To give information anonymously contact Crimestoppers on 0800 555 111 or via the crimestoppers-uk.org web site.